One Health is a cross-disciplinary effort aiming to improve the assessment, treatment, and prevention of disease in people and animals. An important subfield of One Health is comparative medicine, which offers the possibility to use spontaneous animal models with naturally occurring diseases for drug R&D. These animal models have unique experimental advantages, especially over the mouse, which may provide insight into previously intractable diseases. In particular, many human disorders, including cancer, diabetes mellitus, chronic enteropathies (e.g., inflammatory bowel diseases), hypertension, and congestive heart failure have well-studied clinical analogs in dogs. SMART pharmacology is committed to advancing healthcare in animals as well as humans through the use of analytical modeling.