In Pharmacokinetic studies, researchers use a controlled research environment to determine the biological fate of a pharmaceutical after administration. In practice, this means determining the typical plasma concentration of the drug from the moment of administration until effective elimination of the drug from the body. From this typical profile, researchers can predict useful clinical metrics like the predicted maximum concentration (Cmax) of the pharmaceutical and the time it takes for the drug to reach peak plasma concentration (Tmax ) after administration. (more…)
In this manuscript, we use a nonlinear mixed effects (NLME) framework to develop a compartmental model of vitacoxib disposition kinetics in dogs after intravenous (I.V), oral (P.O) and subcutaneous (S.C) dosing. The influence of age, sex, bodyweight and food intake were evaluated as covariates on model parameters to assess the need for dose adjustment of vitacoxib in dogs.
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