Jianzhong Wang

IMG_20180608_070547R

I received a Bachelor of Veterinary Medicine in 2013 and a Master of Veterinary Medicine in Pharmacology and Toxicology in 2014 from the College of Veterinary Medicine, China Agricultural University. Currently, I am completing my Ph.D. in veterinary pharmacology and toxicology at China Agricultural University, and expect to defend by June 2020. During my veterinary Ph.D. studies, I was a one-year visiting scholar at Iowa State University, learning about pharmacokinetics and pharmacodynamic modeling, from Oct 2018 to Oct 2019.

During my veterinary undergraduate studies (5 years), I was a Medical Internship in Veterinary Medicine at China agricultural university veterinary teaching hospital (2012-2013). My Master’s and PhD’s lab is National Center for Veterinary Drug Safety Evaluation (Beijing) which researches, develop and evaluates Investigational New Drug in cooperation with veterinary drug enterprises. My research focus is pre-clinical veterinary pharmaceutical evaluation (pharmacokinetics & pharmacodynamics) and veterinary drug residue detection. I participated in numerous and rigorous projects of GCP compliance. My previous work has been in refining our collective understanding of the pharmacokinetics and bioequivalence of veterinary non-steroidal anti-inflammatories, steroidal anti-inflammatories, and antibiotics. I have established many sensitive and analytical methods for pharmacokinetics and bioequivalent studies, while these methods have been well validated, including nonsteroidal and steroid drugs. A series of analytic and toxicological studies were conducted in our laboratory in the past five years.

Publications:

2021

  1. He Jinxin, Yan Zheng, Xiaorong Chen, Na Li, Fang Tang, Nairui Huo, Jianzhong Wang*and Shaopeng Gu*. Development of an enzyme-linked immunosorbent assay for the detection of mebendazole in chicken and mutton. Analytical Methods. 13:1740–1746.

2020

  1. Jianzhong Wang, Benjamin Karl Schneider, Hongzhi Xiao, Jicheng Qiu, Xiaohui Gong, Yeon-Jung Seo, Jing Li, Jonathan Paul Mochel* and Xingyuan Cao*. (2020) Nonlinear Mixed-Effects Pharmacokinetic Modeling of the Novel COX-2 Selective Inhibitor Vitacoxib in Cats. Frontiers in Veterinary Science. 7: 654.
  2. Jianzhong Wang, Jicheng Qiu, Xiaohui Gong, Pan Sun, Jing Li, Suxia Zhang* & Xingyuan Cao*. (2020). Pharmacokinetics of three formulations of vitacoxib in horses. Journal of Veterinary Pharmacology and Therapeutics. 43(4):364-368.

2019

  1. Jianzhong Wang, Xiaohui Gong, Jiao Xue, Suxia Zhang, Jing Li, Xingyuan Cao*. (2019) Pharmacokinetics of the novel COX-2 selective inhibitor vitacoxib in cats: The effects of feeding and dose. Journal of Veterinary Pharmacology and Therapeutics, 42(3):294-299.
  2. Jianzhong Wang, Jiao Xue, Lu Zhang, Suxia Zhang, Jing Li, Xingyuan Cao*. (2019). Pharmacokinetics of vitacoxib in rabbits after intravenous and oral administration. Journal of Veterinary Pharmacology and Therapeutics, 42(3), 368-371.
  3. Jianzhong Wang, Benjamin K. Schneider, Pan Sun, Xiaohui Gong, Jicheng Qiu, Jing Li, Yeon-Jung Seo, Mochel, Jonathan P* & Xingyuan Cao*. (2019) Nonlinear mixed-effects pharmacokinetic modeling of the novel COX-2 selective inhibitor vitacoxib in dogs. Journal of Veterinary Pharmacology and Therapeutics, 42(5), 530-540.
  4. Jianzhong Wang, Benjamin K. Schneider, Jiao Xun, Pan Sun, Jicheng Qiu, Jing Li, Yeon-Jung Seo, Jonathan Paul Mochel * & Xingyuan Cao*. (2019) Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs. Frontiers in Veterinary Science. 6:363.

2018

  1. Jianzhong Wang, Haoyuan Peng, Jingyuan Kong, Tingting Zhao, Suxia Zhang, Xingyuan Cao*. (2018) Pharmacokinetic profile of Ceftiofur Hydrochloride Injection in lactating Holstein dairy cows. Journal of Veterinary Pharmacology & Therapeutics. 41(2): 301–306.
  2. Jianzhong Wang, Jiao Xue, Jingyuan Kong, Jing Li, Suxia Zhang and Xingyuan Cao* (2018). Evaluation of pharmacokinetic properties of vitacoxib in fasted and fed horses. Journal of Veterinary Pharmacology & Therapeutics 41(6): 843-847.
  3. Jianzhong Wang, Tingting Zhao, Shusheng Tang, Suxia Zhang, Pengyyue Lv, Jing Li, and Xingyuan Cao*. (2018). Safety assessment of vitacoxib: 180-day chronic oral toxicity studies. Regulatory Toxicology and Pharmacology 95:244-249.
  4. Jianzhong Wang, Feifei Sun, Shusheng Tang, Suxia Zhang, Jing Li, and Xingyuan Cao* (2018) Mutagenicity and teratogenicity studies of vitacoxib in rats and mice. Toxicology Reports 5:827-831.

2017

  1. Jianzhong Wang, Tingting Zhao, Jingyuan Kong, Haoyuan Peng, Pengyue Lv, Jing Li, Xingyuan Cao* and Suxia Zhang*. (2017) Determination of vitacoxib, a novel COX-2 inhibitor, in equine plasma using UPLC–MS/MS detection: Development and validation of new methodology. Journal of Chromatography B 1061–1062, 270-274.
  2. Jianzhong Wang., Tingting Zhao, Xinya Sun, Yiduo Liu, Jingru Zhu, Suxia Zhang, and Xingyuan Cao*. (2017). Pharmacokinetics of tildipirosin in beagle dogs.  Journal of Veterinary Pharmacology & Therapeutics 41(1): e49–e52.
  3. Jianzhong Wang, Feifei Sun, Shusheng Tang, Suxia Zhang, Pengyue Lv, Jing Li, and Xingyuan Cao*. (2017). Safety assessment of vitacoxib: Acute and 90-day sub-chronic oral toxicity studies. Regulatory Toxicology and Pharmacology 86:49-58.
  4. Jianzhong Wang, Zhiyuan Li, Feifei Sun, Shusheng Tang, Suxia Zhang, Pengyyue Lv, Jing Li, and Xingyuan Cao*. (2017). Evaluation of dermal irritation and skin sensitization due to vitacoxib. Toxicology Reports 4:287-290.

2015

  1. Jianzhong Wang, Feifei Sun, Shusheng Tang, Suxia Zhang, Xingyuan Cao* (2015). Acute, mutagenicity, teratogenicity and subchronic oral toxicity studies of diaveridine in rodents. Environmental Toxicology and Pharmacology, 40(2), 660-670.