Dr. Jon Mochel obtained his Veterinary Medical Degree from the National Veterinary School of Toulouse. In 2007, he completed his Doctorate studying Neurosciences in collaboration with the College de France (Paris), and received the Silver Medal from the National Veterinary School of Alfort for his work.
During his veterinary undergraduate studies Dr. Mochel also obtained a Masters in Pharmacology and Pharmacokinetics (2006) from the University of Toulouse. Following a Medical Internship in Veterinary Medicine and Surgery at Maisons-Alfort (2006-2008), he also got a Master of Science (MS) in Pharmacology and Pharmacokinetics from the University of Toulouse. He then pursued a 4-year Specialization program in Pharmacology and Toxicology (European Board) and earned his title of European Specialist in Veterinary Pharmacology and Toxicology.
Dr. Mochel did his Ph.D at Leiden University under the supervision of Pr. Meindert Danhof, whose focus was on the modeling of the dynamics of the renin-angiotensin aldosterone system (RAAS) in dogs.
In 2012, he co-founded the Animal Health Modeling & Simulation (AHM&S) Society, together with Pr. Johan Gabrielsson (University of Agricultural Sciences, Uppsala, Sweden), and Pr. Jim Riviere (Kansas State University, USA), which aims at promoting the development, application, and dissemination of Modeling and Simulation techniques in the field of Veterinary Sciences (http://www.ahmss.com/).
Since joining Novartis Pharmaceuticals in 2013, he had been working as a Senior Pharmacology Modeler in the Modeling and Simulation (M&S) group formed by Dr. Donald Stanski. He thereafter operated as a Quantitative Pharmacology Leader in the Research M&S department of Dr. Thierry Lave at Roche.
Dr. Mochel is currently an Associate Professor in the Department of Biomedical Sciences at Iowa State University and the Chair of the Education and Residency Committee of the European College of Pharmacology and Toxicology (http://www.ecvpt.org/).
His research, which falls under the scope of the One Health initiative, pertains to the analysis of clinical data obtained from spontaneous animal models of human diseases to bridge the knowledge gap between experimental (i.e rodent) models and patients.
Accepted Peer-Reviewed Manuscripts
Pharmacokinetics and PK/PD Modeling
[1] Vaghi C, Rodallec A, Fanciullino R, Ciccolini J, Mochel JP, Mastri M, Ebos JML, Poignard C, Benzekry S. Population Modeling of Tumor Growth Curves Identifies a Reduced Gompertz Model and Improves Prediction of Tumor Initiation Time. PLoS Comput Biol. 2020;16(2):e1007178. DOI:10.1371/journal.pcbi.1007178. PMID: 32097421.
[2] Sebbag L, Kirner N, Allbaugh R, Mochel JP. Pharmacokinetics of Topical Drug Delivery: Does Size Really Matter? Front Vet Sci. 2019 Dec 19;6:457. DOI: 10.3389/fvets.2019.00457. PMID: 31921915.
[3] Musser M, Mahaffey AL, Fath M, Buettner G, Brett W, Schneider B, Seo YJ, Mochel JP, Johannes CM. In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs. Front Vet Sci. 2019 Nov 7;6:385. DOI: 10.3389/fvets.2019.00385. PMID: 31788483.
[4] Smith JS, Borts DJ, Slagel CC, Rajewski SM, Bousquet-Melou A, Ferran AA, Plummer PJ, Mochel JP. Pharmacokinetics of Ertapenem in Sheep (Ovis aries) with Experimentally Induced Urinary Tract Infection. Comp Med. 2019 Oct 1;69(5):413-418. DOI: 10.30802/AALAS-CM-18-000144. PMID: 31581974.
[5] Wang J, Schneider BK, Xue J, Sun P, Qiu J, Mochel JP*, Cao X*. Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs. Front Vet Sci. 2019 Oct 17;6:363. DOI: 10.3389/fvets.2019.00363. PMID: 31681816. *: co-corresponding author.
[6] Tinklenberg RL, Murphy SD, Mochel JP, Seo YJ, Mahaffey AL, Yan Y, Ward JL. Dose-Response Effects of Oral Short-Term Prednisone Therapy on Clinicopathologic and Hemodynamic Variables in Healthy Dogs. Am J Vet Res. 2020;81(4):317–325. DOI:10.2460/ajvr.81.4.317. PMID: 32228253.
[7] Martinez M, Boopathy S*, Carlert S*, Jamei M*, Mochel JP* and Vertzoni M*. Workshop Report: USP Workshop on Exploring the Science of Drug Absorption. Dissol Technol. 2019. DOI: 10.14227/DT260319P38. *: equal contributions.
[8] Sebbag L, Yan Y, Smith JS, Allbaugh RA, Wulf LW, Mochel JP. Tear Fluid Pharmacokinetics Following Oral Prednisone Administration in Dogs With and Without Conjunctivitis. J Ocul Pharmacol Ther. 2019 May 9. DOI: 10.1089/jop.2019.0020. PMID: 31070497.
[9] Wang J, Sun P, Li J, Pei Y, Schneider BKS, Seo YJ, Mochel JP* and Cao X*. Nonlinear Mixed-Effects Pharmacokinetic Modeling of the Novel COX-2 Selective Inhibitor Vitacoxib in Dogs. J Vet Pharmacol Ther. 2019. DOI: 10.1111/jvp.12802. PMID: 31369157. *: co-corresponding author.
[10] Smith JS, Mochel JP, Borts D, Griffith R. Effects of Experimentally-Induced Respiratory Disease on the Pharmacokinetics and Tissue Disposition of Tulathromycin in Meat Goats. J Vet Pharmacol Ther. 2019 Jun 10. DOI: 10.1111/jvp.12764. PMID: 31183876.
[11] Schneider BKS, Boyer A, Ciccolini J, Wang K, Benzekry S, Mochel JP. Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer. CPT Pharmacometrics Syst Pharmacol. 2019 Apr 19. DOI: 10.1002/psp4.12415. PMID: 31004380.
[12] Moczarnik J, Berger DJ, Noxon JO, LeVine DN, Lin Z, Coetzee JF, Mochel JP. Relative Oral Bioavailability of Two Amoxicillin-Clavulanic Acid Formulations in Healthy Dogs: A Pilot Study. J Am Anim Hosp Assoc. 2019 Jan/Feb;55(1):14-22. DOI: 10.5326/JAAHA-MS-6872. Epub 2018 Nov 14. PMID: 30427713.
[13] Smith JS, Mochel JP, Borts DJ, Lewis KA, Coetzee JF. Adverse Reactions to Fentanyl Transdermal Patches in Calves: A Preliminary Clinical and Pharmacokinetic Study. Vet Anaesth Analg. 2018 Jul;45(4):575-580. DOI: 10.1016/j.vaa.2018.02.009. Epub 2018 Apr 11. PMID: 29880278.
[14] Smith JS, Coetzee JF, Fisher IWG, Borts DJ, Mochel JP. Pharmacokinetics of Fentanyl Citrate and Norfentanyl in Holstein Calves and Effect of Analytical Performances on Fentanyl Parameter Estimation. J Vet Pharmacol Ther. 2018 Aug;41(4):555-561. DOI: 10.1111/jvp.12501. Epub 2018 Mar 30. PMID: 29603262.
[15] Gorden PJ, Ydstie JA, Kleinhenz MD, Brick TA, Smith JS, Griffith RW, Wulf LW, Rajewski SM, Zhang M, Sidhu PK, Mochel JP, Coetzee JF. Comparative Plasma and Interstitial Fluid Pharmacokinetics and Tissue Residues of Ceftiofur Crystalline-Free Acid in Cattle with Induced Coliform Mastitis. J Vet Pharmacol Ther. 2018 Jul 4. DOI: 10.1111/jvp.12688. PMID: 29971798.
[16] Gorden PJ, Burchard M, Ydstie JA, Kleinhenz MD, Wulf LW, Rajewski SJ, Wang C, Gehring R, Mochel JP, Coetzee JF. Comparison of Milk and Plasma Pharmacokinetics of Meloxicam in Postpartum versus Mid-Lactation Holstein cows. J Vet Pharmacol Ther. 2018 Jun;41(3):463-468. DOI: 10.1111/jvp.12488. Epub 2018 Feb 11. PMID: 29430684.
[17] Bon C, Toutain PL, Concordet D, Gehring R, Martin-Jimenez T, Smith J, Pelligand L, Martinez M, Whittem T, Riviere JE, Mochel JP. Mathematical Modeling and Simulation in Animal Health. Part III: Using Nonlinear Mixed-Effects to Characterize and Quantify Variability in Drug Pharmacokinetics. J Vet Pharmacol Ther. 2018 Apr;41(2):171-183. DOI: 10.1111/jvp.12473. Epub 2017 Dec 11. Review. PMID: 29226975.
[18] Martinez MN*, Gehring R*, Mochel JP*, Pade D*, Pelligand L*. Population Variability in Animal Health: Influence on Dose-Exposure-Response Relationships: Part II: Modelling and Simulation. J Vet Pharmacol Ther. 2018 Aug;41(4):E68-E76. DOI: 10.1111/jvp.12666. PMID: 29806231. *: equal contributions.
[19] Bieth B, Bornkamp B, Toutain C, Garcia R, Mochel JP. Multiple Comparison Procedure and Modeling: A Versatile Tool for Evaluating Dose-Response Relationships in Veterinary Pharmacology- A Case Study with Furosemide. J Vet Pharmacol Ther. 2016 Dec;39(6):539-546. DOI: 10.1111/jvp.12313. Epub 2016 May 11. PMID: 27166146.
[20] Pelligand L, Soubret A, King JN, Elliott J, Mochel JP. Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats. CPT Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):625-635. DOI: 10.1002/psp4.12141. PMID: 27770596.
[21] Lin Z, Gehring R, Mochel JP, Lavé T, Riviere JE. Mathematical Modeling and Simulation in Animal Health - Part II: Principles, Methods, Applications, and Value of Physiologically Based Pharmacokinetic Modeling in Veterinary Medicine and Food Safety Assessment. J Vet Pharmacol Ther. 2016 Oct;39(5):421-38. DOI: 10.1111/jvp.12311. Epub 2016 Apr 17. PMID: 27086878.
[22] Riviere JE, Gabrielsson J, Fink M, Mochel J. Mathematical Modeling and Simulation in Animal Health. Part I: Moving Beyond pharmacokinetics. J Vet Pharmacol Ther. 2016 Jun;39(3):213-23. DOI: 10.1111/jvp.12278. PMID: 26592724.
[23] Mochel JP, Fink M, Peyrou M, Soubret A, Giraudel JM, Danhof M. Pharmacokinetic-Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with Benazepril in Dogs. Pharm Res. 2015 Jun;32(6):1931-46. DOI: 10.1007/s11095-014- 1587-9. PMID: 25446774.
[24] Mochel JP, Danhof M. Chronobiology and Pharmacologic Modulation of the Renin- Angiotensin- Aldosterone System in Dogs: What Have We Learned? Rev Physiol Biochem Pharmacol. 2015;169:43-69. DOI: 10.1007/112_2015_27. PMID: 26428686.
[25] Mochel JP, Fink M, Bon C, Peyrou M, Bieth B, Desevaux C, Deurinck M, Giraudel JM, Danhof M. Influence of Feeding Schedules on the Chronobiology of Renin Activity, Urinary Electrolytes and Blood Pressure in Dogs. Chronobiol Int. 2014 Jun;31(5):715-30. DOI: 10.3109/07420528.2014.897711. Epub 2014 Mar 21. PMID: 24654920.
[26] Mochel JP, Fink M, Peyrou M, Desevaux C, Deurinck M, Giraudel JM, Danhof M. Chronobiology of the Renin Angiotensin Aldosterone System in Dogs: Relation to Blood Pressure and Renal Physiology. Chronobiol Int. 2013 Nov;30(9):1144-59. PMID: 23931032.
[27] Fink M, Letellier I, Peyrou M, Mochel JP, Jung M, King JN, Gruet P, Giraudel JM. Population Pharmacokinetic Analysis of Blood Concentrations of Robenacoxib in Dogs with Osteoarthritis. Res Vet Sci. 2013 Oct;95(2):580-7. DOI: 10.1016/j.rvsc.2013.04.021. Epub 2013 May 31. PMID: 23726662.
[28] Mochel JP, Gabrielsson J, Collard W, Fink M, Gehring R, Laffont C, Liu Y, Martin-Jimenez T, Pelligand L, Steimer JL, Toutain PL, Whittem T, Riviere J. Animal Health Modeling & Simulation Society: A New Society Promoting Model-Based Approaches in Veterinary Pharmacology. J Vet Pharmacol Ther. 2013 May 29. DOI: 10.1111/jvp.12060. PMID: 23713757.
Experimental Pharmacology
[29] Ambrosini YM, Park Y, Jergens AE, Shin W, Mon S, Atherly T, Borcherding DC, Jang J, Allenspach K, Mochel JP* and Kim HY*. Recreation of an Accessible Interface of the Biopsy-Derived Canine Intestinal Organoids to Study Epithelial-Luminal Interactions. PLoS One. 2020 (In Press). *: co-corresponding author.
[30] Sebbag L, Moody L, Mochel JP. Albumin Levels in Tear Film Modulate The Bioavailability of Medically-Relevant Topical Drugs. Front Pharmacol. 2020;10:1560. DOI:10.3389 fphar.2019.01560. PMCID: PMC6997149.
[31] Sebbag L, Uhl LK, Schneider B, Hayes B, Olds J, Mochel JP. Schirmer Tear Test is a Reliable Diagnostic Tool in the General Feline Population. J Am Vet Med Assoc. 2020 Mar 15;256(6):681-686. DOI: 10.2460/javma.256.6.681. PMID: 32125244.
[32] Ward J, Mochel JP, Seo YJ, Sathe S. Effects of the Estrous Cycle and Pregnancy Status on Cardiovascular Variables in Healthy Bitches. J Vet Cardiol. 2020 (In Press).
[33] Smith JS, Mochel JP. A Retrospective Clinical Investigation of the Toxicity and Adverse Effects of Pantoprazole in Hospitalized Ruminants. Front Vet Sci. 2020;7:97. DOI:10.3389/fvets.2020.00097. PMID: 32258063.
[34] Sebbag L, Moody L, Allbaugh R, Mochel JP. Nerve Growth Factor in Dogs: Assessment of Two Immunoassays and Selected Ocular Parameters Following a Nicergoline Challenge Per Os. Vet Ophthalmol. 2019 Nov 27. DOI: 10.1111/vop.12723. PMID: 31774231.
[35] Smith JS, Kreuder A, Dowling P, Dohlman T, Plummer P, Toutain PL, Mochel JP. Risks of Antimicrobial Resistance with the Treatment of Bovine Semen with Enrofloxacin. Biopreserv Biobank. 2019 Nov 1. DOI: 10.1089/bio.2019.0068. PMID: 31339769.
[36] Khelik IA, Berger DJ, Mochel JP, Seo YJ, Palerme JS, Ware WA, Ward JL. Clinicopathologic, Hemodynamic, and Echocardiographic Effects of Short-Term Anti-Inflammatory Glucocorticoid Treatment in Systemically Healthy Cats. Am J Vet Res. 2019 Aug;80(8):743-755. DOI: 10.2460/ajvr.80.8.743. PMID: 31339769.
[37] Sebbag L, Allbaugh R, Wehrman R, Uhl L, Ben-Shlomo G, Chen T, Mochel JP. Fluorophotometric Assessment of Tear Volume and Turnover Rate in Healthy Dogs and Cats. J Ocul Pharmacol Ther. 2019 Aug 8. DOI: 10.1089/jop.2019.0038. PMID: 31381493.
[38] Sebbag L, Allbaugh RA, Weaver A, Seo YJ, Mochel JP. Histamine-Induced Conjunctivitis and Breakdown of Blood-Tear Barrier in Dogs: A Model for Ocular Pharmacology and Therapeutics. Front Pharmacol. 2019 Jul 9;10:752. DOI: 10.3389/fphar.2019.00752. eCollection 2019. PMCID: PMC6629934.
[39] Lerch M, Allbaugh R, Sebbag L, Mochel JP, Weller P, Borts DJ. Paper Spray High–Resolution Accurate Mass Spectrometry for Quantitation of Voriconazole in Equine Tears. Anal Bioanal Chem. 2019 May 23. DOI: 10.1007/s00216-019-01898-9. PMID: 31123782.
[40] Uhl LK, Saito A, Iwashita H, Maggs DJ, Mochel JP, Sebbag L. Clinical Features of Cats with Aqueous Tear Deficiency: A Retrospective Case Series of 10 Patients (17 eyes). J Feline Med Surg. 2018 Nov 12:1098612X18810867. DOI: 10.1177/1098612X18810867. PMID: 30417738.
[41] Sebbag L, Showman L, McDowell EM, Perera A, Mochel JP. Impact of Flow Rate, Collection Devices, and Extraction Methods on Tear Concentrations Following Oral Administration of Doxycycline in Dogs and Cats. J Ocul Pharmacol Ther. 2018 Apr 30. DOI: 10.1089/jop.2018.0008. PMID: 29708819.
[42] Sebbag L, McDowell EM, Hepner PM, Mochel JP. Effect of Tear Collection on Lacrimal Total Protein Content in Dogs and Cats: A Comparison Between Schirmer Strips and Ophthalmic Sponges. BMC Vet Res. 2018 Mar 1;14(1):61. DOI: 10.1186/s12917-018-1390-7. PMID: 29490661.
[43] Sebbag L, Harrington DM, Mochel JP. Tear Fluid Collection in Dogs and Cats Using Ophthalmic Sponges. Vet Ophthalmol. 2018 May;21(3):249-254. DOI: 10.1111/vop.12502. Epub 2017 Aug 27. PMID:28845579.
[44] Masters AK, Berger DJ, Ware WA, Langenfeld NR, Coetzee JF, Mochel JPM, Ward JL. Effects of Short-Term Anti-Inflammatory Glucocorticoid Treatment on Clinicopathologic, Echocardiographic, and Hemodynamic Variables in Systemically Healthy Dogs. Am J Vet Res. 2018 Apr;79(4):411- 423. DOI: 10.2460/ajvr.79.4.411. PMID: 29583045.
[45] Berger EP, Johannes CM, Jergens AE, Allenspach K, Powers BE, Du Y, Mochel JP, Fox LE, Musser ML. Retrospective Evaluation of Toceranib Phosphate (Palladia) Use in the Treatment of Gastrointestinal Stromal Tumors of Dogs. J Vet Intern Med. 2018 Nov;32(6):2045-2053. DOI: 10.1111/jvim. PMID: 30307656.
[46] Mochel JP, Teng CH, Peyrou M, Giraudel J, Danhof M, Rigel DF. Sacubitril/Valsartan (LCZ696) Significantly Reduces Aldosterone and Increases cGMP Circulating Levels in a Canine Model of RAAS Activation. Eur J Pharm Sci. 2018 Nov 30;128:103-111. DOI: 10.1016/j.ejps.2018.11.037. PMID: 30508581.
[47] Mochel JP, Tyden E, Hellmann K, Vendrig JC, Şenel S, Dencker L, Cristina RT, Linden H, Schmerold I. Network on veterinary medicines initiated by the European Federation For Pharmaceutical Sciences. J Vet Pharmacol Ther. 2018 Jun;41(3):378-383. DOI: 10.1111/jvp.12472. Epub 2017 Dec 20. PMID: 29266320.
[48] Mochel JP, Peyrou M, Fink M, Strehlau G, Mohamed R, Giraudel JM, Ploeger B, Danhof M. Capturing the Dynamics of systemic Renin-Angiotensin-Aldosterone System (RAAS) Peptides Heightens the Understanding of the Effect of Benazepril in Dogs. J Vet Pharmacol Ther. 2013 Apr;36(2):174-80. DOI: 10.1111/j.1365- 2885.2012.01406.x. PMID: 22568394.
[49] Mochel J, Fink M. Response to Letter from Atkins et al. J Vet Pharmacol Ther. 2013 Apr. DOI: 10.1111/jvp.12017.
Comparative Medicine
[50] McLimans K, Collazo Martinez A, Mochel JP, Allenspach K, Willette A. Serum Vitamin B12 and Related Cubilin Genotypes Predict Neural Outcomes Across the AD Spectrum. Br J Nutr. 2020 (In Press).
[51] Kilburn LR, Allenspach K, Jergens AE, Bourgois-Mochel A, Mochel JP, Rossoni Serao M. Digestibility, Fecal Characteristics, and Blood Parameters of Healthy Adult Dogs Fed High-Fat Diets. J Anim Sci. 2020;skaa043. DOI:10.1093/jas/skaa043. PMID: 32047902.
[52] Atherly T, Rossi G, White R, Seo YJ, Allenspach K, Mochel JP, Jergens AE. Glucocorticoid Effects on Mucosal Bacteria in Canine Inflammatory Bowel Disease. PLoS One. 2019 Dec 30;14(12):e0226780. DOI: 10.1371/journal.pone.0226780. PMID: 31887117.
[53] Klinedinst BS, Pappas C, Le S, Yu S, Wang Q, Wang L, Allenspach-Jorn K, Mochel JP, Willette AA. Aging-Related Changes in Fluid Intelligence, Muscle and Adipose Mass, and Sex-Specific Immunologic Mediation: A longitudinal UK Biobank study. Brain Behav Immun. 2019 Sep 9. pii: S0889-1591(19)30653-1. DOI: 10.1016/j.bbi.2019.09.008. PMID: 31513875.
[54] Mochel JP, Ekker SC, Johannes CM, Jergens AE, Allenspach K, Bourgois-Mochel A, Knouse M, Benzekry S, Wierson W, LeBlanc AK, Kenderian S. CAR T-Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds against Hematological Malignancies. AAPS J. 2019 Apr 8;21(3):50. DOI: 10.1208/s12248-019-0322-1. PMID: 30963322.
[55] Ambrosini YM, Borcherding D, Kanthasamy A, Kim HJ, Willette AA, Jergens A, Allenspach K, Mochel JP. The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review. Front Aging Neurosci. 2019 Jun 18;11:130. DOI: 10.3389/fnagi.2019.00130. eCollection 2019. PMCID: PMC6591269.
[56] Jergens AE, Guard BC, Redfern A, Rossi G, Mochel JP, Pilla R, Chandra L, Seo YJ, Steiner JM, Lidbury J, Allenspach K, Suchodolski J. Microbiota-Related Changes in Unconjugated Fecal Bile Acids Are Associated With Naturally Occurring, Insulin-Dependent Diabetes Mellitus in Dogs. Front Vet Sci. 2019 Jun 27;6:199. DOI: 10.3389/fvets.2019.00199. eCollection 2019. PMCID: PMC6610424.
[57] Kathrani A, Lezcano V, Hall EJ, Jergens AE, Mochel JP, Atherly T, Allenspach K. Indoleamine- Pyrrole 2,3-Dioxygenase-1 (IDO-1) mRNA is Over-Expressed in the Duodenal Mucosa and is Negatively Correlated with Serum Tryptophan Concentrations in Dogs with Protein-Losing Enteropathy. PLoS One. 2019 Jun 10;14(6):e0218218. PMID: 31181125.
[58] Kathrani A, Lezcano V, Hall EJ, Jergens AE, Seo YJ, Mochel JP, Atherly T, Allenspach K. IL-13 and IL-33 mRNA are Under-Expressed in the Duodenal Mucosa of German Shepherd Dogs with Inflammatory Bowel Disease. J Vet Intern Med. 2019 Jun 6. DOI: 10.1111/jvim.15544. PMID: 31169944.
[59] Chandra L, Borcherding DC, Kingsbury D, Atherly T, Ambrosini YM, Bourgois-Mochel A, Yuan W, Kimber M, Qi Y, Wang Q, Wannemuehler M, Ellinwood NM, Snella E, Martin M, Skala M, Meyerholz D, Estes M, Fernandez-Zapico M, Mochel JP* and Allenspach K*. Derivation of Adult Canine Intestinal Organoids for Translational Research in Gastroenterology. BMC Biol. 2019 Apr 11;17(1):33. DOI: 10.1186/s12915-019-0652-6. PMID: 30975131.* co-corresponding author.
[60] Allenspach KA, Mochel JP, Du Y, Priestnall SL, Moore F, Slayter M, Rodrigues A, Ackermann M, Krockenberger M, Mansell J; WSAVA GI Standardization Working Group, Luckschander N, Wang C, Suchodolski J, Berghoff N, Jergens AE. Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease. Vet Pathol. 2018 Dec 18:300985818813090. DOI: 10.1177/0300985818813090. PMID: 30563436.
[61] Schneider B, Balbas-Martinez V, Jergens AE, Troconiz IF, Allenspach K, Mochel JP. Model- Based Reverse Translation Between Veterinary and Human Medicine: The One Health Initiative. CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):65-68. DOI: 10.1002/psp4.12262. Epub 2017 Nov 27. PMID: 29178333.
[62] Mochel JP, Jergens AE, Kingsbury D, Kim HJ, Martín MG, Allenspach K. Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research. AAPS J. 2017 Dec 12;20(1):17. DOI: 10.1208/s12248-017-0178-1. Review. PMID: 29234895.
[63] Dencker L, Hellmann K, Mochel J, Senel S, Linden H, Tyden E, Vendrig JC, Schmerold I. EUFEPS Network on Veterinary Medicines Initiative: An Interdisciplinary Forum to Support Veterinary Pharmacology and Promote the Development of New Pharmaceuticals for Animal Health. Eur J Pharm Sci. 2016 August 25; 91:I- VII. DOI: 10.1016/s0928-0987(16)30254-8.
Preprints (Under Review)
[64] Martinez M, Pade D, Mochel JP. Pharmacokinetic Considerations In Inter-Species Comparisons (Submitted: Current Opinion in Toxicology).
[65] Le ST, Cerna J, Klinedinst BS, Frizell B, Mochel JP, Willette AA. Mitochondrial Bioenergetics and Alzheimer’s Disease: Pyruvate Kinase and Associations with Neural and Cognitive Outcomes (Submitted: Neurobiology of Aging).
[66] Pappas C, Klinedinst BS, Le S, Wang Q, Larsen B, McLimans K, Lockhart S, Allenspach K, Mochel JP, Willette A. CSF Glucose Tracks Regional Tau Progression Based on Alzheimer’s Disease Risk Factors (Submitted: Alzheimer and Dementia).
[67] Le ST, Klinedinst BS, Pappas C, Larsen B, Wang Q, Wang Y, Yu S, Wang L, Allenspach K, Mochel JP, Bennett D, Willette AA. More Cheese, Less White Wine: Consumption of Whole Foods, Changes in Fluid Intelligence, and the Influence of Alzheimer’s Disease Genetic Factors (Submitted: Journal of Alzheimer’s Disease).
[68] Klinedinst BS, Meier NF, Mochel JP, Allenspach K, Bennett D, Willette AA. Walking In The Light: How History of Physical Activity, Sunlight, and Vitamin D Levels Account For DEXA-Quantified Body Fat Volumes - a UK Biobank Study (Submitted: Obesity).
[69] Ambrosini YM, Borcherding D, Seo YJ, Segarra S, Glanemann B, Garden OA, Neuber S, Müller U, Dang V, Borts D, Atherly T, Jergens A, Mochel JP, Allenspach K. Treatment with Hydrolyzed Diet Supplemented with Prebiotics and Glycosaminoglycans Alters Lipid Metabolism in a Canine Model of Inflammatory Bowel Disease (Submitted: Frontiers Veterinary Science).
[70] Glanemann B, Seo YJ, Priestnall S, Garden OA, Jergens AE, Segarra S, Mochel JP, Allenspach K. Clinical Efficacy of Prebiotics and Glycosaminoglycans versus Placebo In Dogs with Food Responsive Enteropathy receiving a Hydrolyzed Diet: A Pilot Study (Submitted: Journal of Veterinary Internal Medicine).
[71] Wang J, Schneider BK, Sun P, Seo YJ, Mochel JP*, Cao X*. Nonlinear Mixed-Effects Pharmacokinetic Modeling of the Novel COX-2 Selective Inhibitor Vitacoxib in Cats (Submitted: Frontiers in Veterinary Science). *: co-corresponding author.
[72] Kittrell HC, Mochel JP, Brown J, Schneider BK, Ratliffe B, Karriker L. Pharmacokinetics and Bioavailability of Flunixin Meglumine in Pre-Wean Piglets Following Oral, Topical, and Intramuscular Routes of Administration (Submitted: Frontiers in Veterinary Science).
[73] Smith JS, Mochel JP, Seo YJ, Ahrens AP, Griffith RW. Preliminary Evaluation of a Pasteurella Multocida Respiratory Disease Induction Model for Goats (Submitted: Journal of the American Association for Laboratory Animal Science).
[74] Sebbag L, Soler E, Allbaugh R, Mochel JP. Impact of Acute Conjunctivitis on Ocular Surface Homeostasis in Dogs (Submitted: Veterinary Ophthalmology).
[75] Coto GM, Musser ML, Tropf M, Ward JL, Seo YJ, Mochel JP, Johannes CM. A multi-Institutional Retrospective Analysis of Prognostic Factors and Treatment Options for Presumed or Confirmed Canine Aortic Body Chemodectomas (Submitted: Journal of Veterinary Cardiology).
[76] Terhaar HM, Allbaugh RA, Mochel JP, Sebbag L. Serum Albumin and Total Protein Concentration in the Tear Film of Horses with Healthy or Diseased Eyes (Submitted: Veterinary Ophthalmology).
[77] Naiman JH, Zellner EM, Petrovsky BL, Riegel TO, Yuan L, Mochel JP, Schmitt EM, Kraus KH. Percutaneous Fluoroscopically Guided Lag Screw Fixation for Sacroiliac Luxation in Dogs (Submitted: Veterinary Surgery).
[78] Heinrich ERE, Levine DN, Walton R, Gonzales J, Seo YJ, Mochel JP, Allenspach K. Retrospective Comparison of a Novel Continuous Insulin Infusion Protocol to Standard Of Care Treatment for Diabetic Ketoacidosis in Dogs (Submitted: Journal of Veterinary Internal Medicine).
In Preparation
[79] Allenspach K, Borcherding DC, Lennarella-Servantez C, Ambrosini Y, Atherly T, Bourgois-Mochel A, Rossoni M, Kilburn L, Jergens AE, Mochel JP. Unfavorable Changes in the Gut Microbiome, Intestinal Epithelium and Serum Metabolome Induced by Short-Term High-Fat Diets (Science Translational Medicine).
[80] Sebbag L, Mochel JP. An Eye on the Dog as the Scientist’s Best Friend for Translational Research in Ophthalmology: A Focus on the Ocular Surface (Medicinal Research Reviews).
[81] Borcherding D, Chandra L, Jergens AE, Atherly T, Bourgois-Mochel A, Martin M, Allenspach K, Mochel JP. Differential Transcriptomic Profiles in Response to LPS Stimulated Canine Intestinal Organoids (PLoS One).
[82] Vessieres F, Du Y, Jergens AE, Procoli F, Logue CM, Wang C, Mochel JP, Allenspach K. Specific Virulence Factors in Mucosa-Associated E. coli of Dogs With Inflammatory Bowel Disease (IBD) are Associated with Survival (PLoS One).
[83] Seo YJ, Smith JS, Borts D, Coetzee JF, Ayral G, Mochel JP. Pharmacokinetic Modeling of Fentanyl Citrate and Norfentanyl in Holstein Calves Using a Nonlinear Mixed-Effects Approach (Frontiers in Veterinary Science).
[84] Yaeger M, Mochel JP, Wu Z, Plummer P, Sahin R, Beyi A, Zhang Q, Griffith R. Pharmacokinetics of Tulathromycin in Pregnant Ewes Challenged with Campylobacter Jejuni. (Frontiers in Veterinary Science).
[85] Ambrosini Y, Borcherding D, Lennarella C, Atherly T, Martinez M, Jergens AE, Allenspach K, Mochel JP. A Novel Canine In Vitro Model for Investigation of Intestinal P-Glycoprotein-Mediated Drug Transport (AAPS Journal).
[86] Martinez M, Pade D, Mochel JP. Comparison of Dog and Human Physiology, Transporter and Enzyme Activity/Location (AAPS Journal).
[87] Hanson KR, Rudloff E, Yuan L, Mochel JP, Linklater AKJ. The Effect of Prazosin on Feline Recurrent Urethral Obstruction (Veterinary Surgery).
[88] Smith JS, Plummer P, Ferran A, Bousquet-Melou A, Mochel JP. Concurrent Use of an Immunostimulant and Antibiotic Improves Treatment Outcome in a Sheep Model of Catheter Associated Urinary Tract Disease Due to P. aeruginosa (Frontiers in Microbiology).
[89] Sebbag L, Kirner NS, Wulf L, Mochel JP. Tear Film Pharmacokinetics and Systemic Absorption of Topical 1% Prednisolone Acetate Ophthalmic Suspension in Dogs (Frontiers in Veterinary Science).
Invited Abstracts and Conference Papers (Last six years)
[1] Kurr L, Allenspach K, Atherly T, Borcherding DC, Jergens AE, Mochel JP. Harnessing the Power of Intestinal Stem Cells to Accelerate Drug Discovery in Inflammatory Bowel Disease: A One Health Approach. Capitol Hill Conference, Washington (2020).
[2] Kurr L, Allenspach K, Mao S, Atherly T, Borcherding D, Ambrosini Y, Seo YJ, Jergens AE, Mochel JP. Harnessing The Biology of Intestinal Organoids To Accelerate Drug Discovery in Inflammatory Bowel Disease. American Society for Biochemistry and Molecular Biology, San Diego (2020).
[3] Mochel JP. Reverse Translational Pharmacology: Paradigm Shift or Flash in the Pan. European Federation for Pharmaceutical Sciences, Gothenburg (2020).
[4] Mochel JP. Complexity is Overrated: Back to the Basics of the Renin-Angiotensin Aldosterone System. Translational RAAS Interest Group, Las Vegas (2020).
[5] Ward J, Mochel JP. Rational Dose Selection for ACE Inhibitors in Canine Heart Diseases. Translational RAAS Interest Group, Las Vegas (2020).
[6] Schneider BK, Benzekry S, Mochel JP. A Semi-Mechanistic PK/PD Model of Bevacizumab-Cytotoxic Combination Therapy For Dosing Scheduling Optimization in Non-Small Cell Lung Cancer. Quantitative Systems Pharmacology Conference, Leiden (2020).
[7] Borcherding D, Atherly T, Bourgois-Mochel A, Rossoni M, Kilburn L, Ambrosini Y, Perez B, Gabriel V, Lenarella-Servantez C, Mao S, Jergens AE, Mochel JP and Allenspach K. Polyphenols Reverse the Pathologic Effects of Palmitic Acid and High Fat Diet in Canine Enteroids. Digestive Disease Week, Chicago (2020). Poster of Distinction (Top 10%).
[8] Allenspach K, Phillips G, Jergens AE, Mochel JP. Short-term High Fat/Low Carbohydrate Diet in Dogs Induces Dysbiosis of the Microbiome Analogous to Obesity in People. Society for Mucosal Immunology, Denver (2020).
[9] Moody LM, Mochel JP, Soler EA, Sebbag L. Albumin in Tear Film Decreases the Bioavailability of Topical Tropicamide and Latanoprost in Dogs. American College of Veterinary Ophthalmologists Conference, Hawaii (2019).
[10] Soler EA, Mochel JP, Allbaugh RA, Moody LM, Sebbag L. Impact of Acute Conjunctivitis on Tear Film Dynamics, Quantity and Quality in Healthy Beagle Dogs. American College of Veterinary Ophthalmologists Conference, Hawaii (2019).
[11] Sebbag L, Yan Y, Smith JS, Allbaugh RA, Wulf LW, Mochel JP. Tear Fluid Pharmacokinetics Following Oral Prednisone Administration In Dogs With or Without Conjunctivitis. American College of Veterinary Ophthalmologists Conference, Hawaii (2019).
[12] Schneider BK, Boyer A, Ciccolini J, Barlesi F, Wang K, Benzekry S, Mochel JP. Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer. American Conference of Pharmacometrics, Orlando (2019).
[13] Mochel JP. Reconciling Quantitative and Clinical Sciences in VetMed 2.0. European College of Veterinary Internal Medicine Annual Conference, Milan (2019).
[14] Ambrosini Y, Borcherding D, Atherly T, Martinez M, Jergens AE, Allenspach K, Mochel JP. A Novel Canine In Vitro Model for Investigation of Intestinal P-Glycoprotein-Mediated Drug Transport. European College of Veterinary Internal Medicine Annual Conference, Milan (2019).
[15] Jergens AE, Mochel JP, Kilburn L, Atherly T, Bourgois-Mochel A, Borcherding D, Ambrosini Y, Allenspach K. Effect of Dietary Fat Content on Mucosal Microbiota and Serum Metabolome in Healthy Beagles. European College of Veterinary Internal Medicine Annual Conference, Milan (2019).
[16] Glanemann B, Seo YJ, Priestnall S, Garden OA, Jergens AE, Segarra S, Mochel JP, Allenspach K. Clinical Efficacy of Prebiotics and Glycosaminoglycans versus Placebo In Dogs with Food Responsive Enteropathy receiving a Hydrolyzed Diet: A Pilot Study. European College of Veterinary Internal Medicine Annual Conference, Milan (2019).
[17] Allenspach K, Jergens AE, Mochel JP. Use of Intestinal Organoids to Improve Predictability of Bioavailability. European College of Veterinary Internal Medicine Annual Conference, Milan (2019).
[18] Vaghi C, Rodallec A, Fanciullino R, Ciccolini J, Mochel JP, Mastri M, Ebos JML, Poignard C, Benzekry S. Population modeling of tumor growth curves: the reduced Gompertz model. International Symposium on Mathematical and Computational Oncology (ISMCO), Lake Tahoe, NV (2019).
[19] Kirner NS, Mochel JP, Allabugh R, Wulf L, Sebbag L. Ocular and Systemic Considerations for Topical Drug Delivery in Dogs. MAF National Veterinary Scholars Symposium, Ames (2019).
[20] Mao S, Atherly T, Borcherding D, Ambrosini Y, Allenspach K, Seo YJ, Mochel JP and Jergens AE. Phenotypic and Functional Characterization of Adult Intestinal Organoids from Dogs with Inflammatory Bowel Disease. National Veterinary Scholars Symposium, Ames (2019).
[21] Martindale A, Mochel JP, Hay-Kraus B, Naiman J, Seo YJ, Petrovsky B, Zellner E. Effect of Intraoperative Antibiotic Administration on Physiological Parameters in Dogs. National Veterinary Scholars Symposium, Ames (2019).
[22] Borcherding D, Ambrosini Y, Atherly T, Phillips R, Hostetter J, Estes M, Fernandez-Zapico ME, Wang K, Martin M, Jergens AE, Allenspach K, Mochel JP. A Novel Canine Enteroid Model for Genome Editing of Multi-Drug Resistance Proteins and Dose-Exposure Response of Chemotherapeutic Drugs. International Society for Stem Cell Research (ISSCR), Los Angeles, CA (2019).
[23] Nelli RK, Atherly T, Allenspach K, Mochel JP, Jergens AE, Gimenez-Lirola GL. Small Intestinal Enteroids on Transwells are Ideal to Study Swine Enteric Corona Viruses. International Society for Stem Cell Research (ISSCR), Los Angeles, CA (2019).
[24] Borcherding D, Ambrosini Y, Segarra S, Glanemann B, Garden O, Atherly T, Jergens AE, Mochel JP, Allenspach K. Treatment with Hydrolyzed Diet Supplemented with Prebiotics and Glycosaminoglycans Improves Abnormalities in Lipid Metabolism in a Canine Model of Inflammatory Bowel Disease. Digestive Disease Week San Diego (2019).
[25] Borcherding D, Ambrosini Y, Atherly T, Phillips R, Hostetter J, Ellinwood NM, Snella E, Estes M, Fernandez-Zapico ME, Wang K, Martin M, Jergens AE, Allenspach K, Mochel JP. CRISPR/CAS9-Mediated Genome Editing of Multi-Drug Resistance Proteins in a Novel Canine Enteroid Model. Digestive Disease Week San Diego (2019).
[26] Ambrosini Y, Borcherding D, Mochel JP, Atherly T, Phillips R, Hostetter J, Ellinwood NM, Snella E, Estes M, Fernandez-Zapico ME, Wang K, Martin M, Jergens AE, Mochel JP, Allenspach K. Molecular Response of Canine Intestinal Organoids to Gastrointestinal Nematode Extracellular Vesicles. Digestive Disease Week San Diego (2019).
[27] Borcherding D, Ambrosini Y, Atherly T, Phillips R, Hostetter J, Ellinwood NM, Snella E, Estes M, Fernandez-Zapico ME, Wang K, Martin M, Jergens AE, Allenspach K, Mochel JP. A Novel Canine Intestinal Organoid Model to Characterize Dose-Exposure-Response of Chemotherapeutic Drugs. Digestive Disease Week San Diego (2019).
[28] Borcherding D, Mochel JP, Ambrosini Y. Atherly T, Phillips R, Hostetter J, Ellinwood NM, Snella E, Estes M, Fernandez-Zapico ME, Wang K, Martin M, Jergens AE, Allenspach K. High-Fat Ketogenic Diet Decreases Serum Lipid Metabolites in Healthy Dogs. Digestive Disease Week San Diego (2019).
[29] Tinklenberg RL, Murphy SD, Mochel JP, Seo YJ, Mahaffey AL, Yan Y, Ward JL. Dose-Response Effects of Oral Short-Term Prednisone Therapy on Clinicopathologic and Hemodynamic Variables in Healthy Dogs. ACVIM Forum, Phoenix, AZ (2019).
[30] Musser M, Mahaffey AL, Fath M, Buettner G, Brett W, Schneider B, Seo YJ, Mochel JP, Johannes CM. In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs. ACVIM Forum, Phoenix, AZ (2019).
[31] Musser M, Mahaffey AL, Fath M, Buettner G, Brett W, Schneider B, Seo YJ, Mochel JP, Johannes CM. In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs. ESVONC, Frankfurt (2019).
[32] Glanemann B, Seo YJ, Priestnall SL, Garden OA, Jergens AE, Segarra-Lopez S, Mochel JP, Allenspach K. Clinical Efficacy of Hydrolyzed Diet With Supplemental Prebiotics and Glycosaminoglycans versus Placebo In Canine Food Responsive Enteropathy: A Pilot Study. ACVIM Forum, Phoenix, AZ (2019).
[33] Ambrosini YM, Borcherding D, Atherly T, Essner J, Wierson W, Kim HY, Jergens AE, Mochel JP*, Allenspach K*. A Novel Canine-Specific Model System to Study P-Glycoprotein-Mediated Drug Transport. *: co-corresponding author. ACVIM Forum, Phoenix, AZ (2019).
[34] Kathrani A, Lezcano V, Hall EJ, Jergens AE, Mochel JP, Atherly T, Allenspach K. Indoleamine- Pyrrole 2,3-Dioxygenase-1 (IDO-1) mRNA is Over-Expressed in the Duodenal Mucosa and is Negatively Correlated with Serum Tryptophan Concentrations in Dogs with Protein-Losing Enteropathy. ACVIM Forum, Phoenix, AZ (2019).
[35] Kathrani A, Lezcano V, Hall EJ, Jergens AE, Seo YJ, Mochel JP, Atherly T, Allenspach K. IL-13 and IL-33 mRNA are Under-Expressed in the Duodenal Mucosa of German Shepherd Dogs with Inflammatory Bowel Disease. ACVIM Forum, Phoenix, AZ (2019).
[36] Heinrich E, Walton R, Blong A, LeVine D, Seo YJ, Mochel JP, Allenspach K. Comparison of a Novel Continuous Insulin Protocol to Standard of Care Treatment for Diabetic Ketoacidosis. ACVIM Forum, Phoenix, AZ (2019).
[37] Schneider BK, Boyer A, Ciccolini J, Barlesi F, Wang K, Benzekry S, Mochel JP. Simulation-based Optimization of Bevacizumab-Pemetrexed/Cisplatin Combination Therapy in Non-Small Cell Lung Cancer. Population Approach Group in Europe (PAGE) Meeting, Stockholm (2019).
[38] Seo YJ, Kanthasamy AG, Allenspach K, de Lange ECM, Mochel JP. Physiologically-Based Pharmacokinetic (PBPK) Model for the Prediction of Levodopa (L-dopa) Disposition in Plasma and Various Brain Compartments Across Species. Population Approach Group in Europe (PAGE) Meeting, Stockholm (2019).
[39] Lerch M, Allbaugh R, Sebbag L, Mochel JP, Weller P, Borts DJ. Paper Spray High – Resolution Accurate Mass Spectrometry for Quantitation of Voriconazole in Equine Tears and Plasma. American Society for Mass Spectrometry Conference, Atlanta (2019).
[40] Allenspach K, Atherly T, Borcherding D, Ambrosini Y, Jergens AE, Kilburn L, Bourgois-Mochel A, Rossoni-Serrao M, Mochel JP. High fat diet increases stemness of intestinal epithelial cells and induces dysbiosis of the mucosal-adherent microbiome in dogs. International Congress of Mucosal Immunology, Brisbane (2019).
[41] Mochel JP. Translational Pharmacology: Paradigm Shift or Flash in the Pan? AAPS PharmSci 360 Conference, Washington (2018).
[42] Mochel JP, Jergens AE, Borcherding D, Ambrosini Y, Fernandez-Zapico M, Kim HY, Allenspach K. Canine Organoids for Drug Testing: Moving Beyond Caco-2 Cell Systems. US Pharmacopeia Workshop on Drug Absorption, Rockville (2018).
[43] Smith JS, Mochel JP. Treatment of Cerebrospinal Nematodiasis in Boer Goats Utilizing a Camelid Therapy Protocol. Neurosciences Research Day, Ames (2018).
[44] Sebbag L, Showman L, McDowell E, Perera A, Mochel JP. Impact of Tear flow, Collection Devices and Extraction Methods on Tear Concentrations Following Oral Administration of Doxycycline in Dogs and Cats. Annual Meeting of the American College of Veterinary Ophthalmologists, Minneapolis (2018).
[45] Sebbag L, Allbaugh RA, Wehrman RF, Uhl L, Chen T, Seo YJ, Mochel JP. Fluorophotometric Assessment of Tear Volume and Turnover Rate in Healthy Brachycephalic and Non-Brachycephalic Dogs and Cats. Annual Meeting of the American College of Veterinary Ophthalmologists, Minneapolis (2018).
[46] Sebbag L, Weaver A, Allbaugh RA, Seo JY, Vogel J, Mochel JP. A Novel In Vivo Model of Conjunctivitis in Dogs. Annual Meeting of the American College of Veterinary Ophthalmologists, Minneapolis (2018).
[47] Uhl L, Saito A, Iwashita H, Maggs DJ, Mochel JP, Sebbag L. Feline Dry Eye Syndrome: Ten Cases (2006- 2018). Annual Meeting of the American College of Veterinary Ophthalmologists, Minneapolis (2018).
[48] Uhl L, Mochel JP, Hayes B, Olds J, Schneider B, Sebbag L. Is Schirmer Tear Test-1 Reliable in the General Feline Population? Annual Meeting of the American College of Veterinary Ophthalmologists, Minneapolis (2018).
[49] Allbaugh RA, Sebbag L, Strong T, Lerch M, Mochel JP, Borts DJ. Evaluation of Voriconazole Concentrations in Equine Tears Following Subconjunctival Injection of Concentrated Antifungal Combined with Thermosensitive Poloxamer Gel. International Equine Ophthalmology Consortium, Reykjavik (2018).
[50] Lerch M, Allbaugh RA, Sebbag L, Mochel JP, Borts D. Paper Spray High-Resolution Accurate Mass Spectrometry for Quantitation of Voriconazole in Equine Tears and Plasma. American Society for Mass Spectrometry Conference, San Diego (2018).
[51] Sebbag L, McDowell EM, Hepner PM, Mochel JP. Effect of Tear Collection on Lacrimal Total Protein Content in Dogs and Cats. Annual meeting of the European College of Veterinary Ophthalmologists, Florence (2018).
[52] Mochel JP, Jergens AE, Chandra L, Kingsbury D, Atherly T, Mochel A, Fernandez-Zapico M, Wang K, Kim HJ, Allenspach K. Canine Organoids for Drug Efficacy and Safety Testing: An Innovative Preclinical Model For Drug Development. International Congress of the European Association of Veterinary Pharmacology and Toxicology, Wroclaw (2018).
[53] Smith JS, Borts D, Coetzee JF, Ayral G, Mochel JP. Pharmacokinetic Modeling of Fentanyl Citrate and Norfentanyl in Holstein Calves Using a Nonlinear Mixed-Effects Approach. International Congress of the European Association of Veterinary Pharmacology and Toxicology, Wroclaw (2018).
[54] Sebbag L, Showman L, McDowell E, Perera A, Mochel JP. A Comparison of Schirmer Strips and Ophthalmic Sponges for Quantifying Doxycycline in Tear Fluid of Dogs and Cats Following Oral Drug Administration. International Congress of the European Association of Veterinary Pharmacology and Toxicology, Wroclaw (2018).
[55] Schneider B, Wang K, Fernandez-Zapico M, Benzekry S, Mochel JP. Measurement Error Modeling of Tumor Volume in a Xenograft Mouse Model of Non-Small Cell Lung Cancer. International Congress of the European Association of Veterinary Pharmacology and Toxicology, Wroclaw (2018).
[56] Mochel JP, Jergens AE, Troconiz I, Balbas V, Benzekry S, Wang K, Fernandez-Zapico M, Allenspach K. Reverse Translational Pharmacology: Paradigm Shift or Flash in the Pan? International Congress of the European Association of Veterinary Pharmacology and Toxicology, Wroclaw (2018).
[57] Smith JS, Slagel C, Borts D, Ferran A, Bousquet-Melou A, Plummer P, Mochel JP. Pharmacodynamics of Ertapenem with and without concurrent use of an Immunostimulant Using an Induced Cystitis Model in Sheep. International Congress of the European Association of Veterinary Pharmacology and Toxicology, Wroclaw (2018).
[58] Smith JS, Mochel JP, Borts D, Griffith R. Pharmacokinetics of Tulathromycin in Healthy Goats and Goats with Induced Pasteurella Multocida Pneumonia. International Congress of the European Association of Veterinary Pharmacology and Toxicology, Wroclaw (2018).
[59] Atherly T, Allenspach K, Mochel JP, Jergens AE. Glucocorticoid Effects on Microbial Community Structure in Canine Inflammatory Bowel Disease. European College of Veterinary Internal Medicine Congress, Rotterdam (2018).
[60] Allenspach K, Mochel JP, Chandra L, Atherly T, Philips R, Hostetter J, Ellinwood NM, Snella L, Estes M, Fernandez-Zapico M, Wang K, Martin M, Jergens AE. Expression of Prostaglandin EP4 Receptor in Canine Jejunum and Enteroids Derived from Healthy Dogs. European College of Veterinary Internal Medicine Congress, Rotterdam (2018).
[61] Kingsbury D, Mochel JP, Atherly T, Chandra L, Philips R, Hostetter J, Wannemuehler M, Jergens AE, Allenspach K. Comparison of Endoscopically (Egd/Colo) Procured Enteroids and Colonoids from Normal Dogs and Dogs with Naturally Occurring Chronic Enteropathies (IBD). Digestive Disease Week (DDW), Washington (2018).
[62] Allenspach K, Mochel JP, Kingsbury D, Chandra L, Atherly T, Philips R, Hostetter J, Qi J, Wang Q, Wannemuehler M, Ellinwood NM, Snella L, Estes M, Martin M, Jergens AE. Functional Characterization of Enteroids/Colonoids From Endoscopically Obtained Biopsies in Healthy and Diseased Dogs. Forum of the American College of Veterinary Internal Medicine, Seattle (2018).
[63] Allenspach K, Mochel JP, Kingsbury D, Chandra L, Atherly T, Bourgois-Mochel A, Borcherding D, Yuan W, Kimber M, Philips R, Hostetter J, Wannemuehler M, Ellinwood NM, Snella L, Jergens AE. Characterization of Paneth-like Cells in the Canine Small Intestine. Forum of the American College of Veterinary Internal Medicine, Seattle (2018).
[64] Smith JS, Mochel JP, Schneider B, Borts D, Griffith RW. Pharmacokinetics of Tulathromycin in Goats with Experimentally-Induced Respiratory Disease. Forum of the American College of Veterinary Internal Medicine, Seattle (2018).
[65] Van Vertloo L, Guard B, Allenspach K, Mochel JP, Park SY, Chandra L, Jergens AE, Suchodolski J. Microbiota-Related Changes in Fecal Bile Acid Metabolism Are Associated With Diabetes Mellitus in Dogs. Forum of the American College of Veterinary Internal Medicine, Seattle (2018).
[66] Khelik I, Berger DJ, Mochel JP, Palerme JS, Ware W, Ward JL. Clinicopathologic, Hemodynamic, and Echocardiographic Effects of Anti-Inflammatory Glucocorticoids in Systemically Healthy Cats. Forum of the American College of Veterinary Internal Medicine, Seattle (2018).
[67] Schneider B, Boyer A, Ciccolini J, Wang K, Zapico-Fernandez M, Benzekry S, Mochel JP. Modeling Primary Tumor Growth in Xenograft Mouse Model of Non-Small Cell Lung Cancer Treated With Pemetrexed-Cisplatin and Bevacizumab. Population Approach Group in Europe (PAGE) Meeting, Montreux (2018).
[68] Yan Y, Mochel JP, Allbauch R, Wulf L, Borts DJ, Sebbag L. Tear Fluid Pharmacokinetics Following Oral Prednisone. ISU College of Veterinary Medicine Summer Symposium, Ames (2018).
[69] Lezcano V, Jergens AE, Atherly T, Chandra L, Borcherding D, Seo YJ, Mochel JP, Kanthrani A, Allenspach K. mRNA Expression of Th2 Cytokines Differs in Duodenal Mucosa of Healthy and Diseased Dogs. ISU College of Veterinary Medicine Summer Symposium, Ames (2018).
[70] Lerch M, Albauch R, Sebbag L, Mochel JP, Borts DJ. Quantitation of Voriconazole in Equine Tears and Plasma via Paper Spray High-Resolution Accurate Mass Spectrometry. ISU College of Veterinary Medicine Winter Symposium, Ames (2018).
[71] Allenspach K, Chandra L, Mochel JP, Jergens A. Targeting IL-1beta; Translational Inflammatory Bowel Disease Research. ISU College of Veterinary Medicine Winter Symposium, Ames (2018).
[72] Kingsbury D, Sun L, Qi Y, Fredericks J, Wang Q, Wannemuehler M, Mochel J, Jergens A, Allenspach K. Optimizing the Development and Characterization of Canine Small Intestinal Crypt Enteroids as a Research Model. International Society for Stem Cell Research Annual Meeting, Boston (2017).
[73] Kingsbury D, Sun L, Qi Y, Fredericks J, Wang Q, Wannemuehler M, Mochel J, Jergens A, Allenspach K. Optimizing the Development and Characterization of Canine Small Intestine Crypt Enteroids as a Research Model. International Congress of Mucosal Immunology, Washington (2017).
[74] Balbas-Martinez V, Allenspach K, Kingsbury D, Jergens AE, Troconiz I, Mochel JP. One Health: Translational and Reverse Translational Modeling of Inflammatory Bowel Disease using an advanced Boolean Network. Population Approach Group in Europe (PAGE) Meeting, Budapest (2017).
[75] Smith JS, Mochel JP, Borts D, Haymond K, Schleining J, Coetzee JF. Pharmacokinetics of Fentanyl and Fentanyl Transdermal Patches in healthy and hospitalized Calves. American College of Veterinary Internal Medicine Forum, Washington (2017).
[76] Mochel JP. Modeling and Simulation: Shifting Gears to Accelerate Understanding of Variability in Animal and Translational Health. American Association of Veterinary Pharmacology and Therapeutics Biennial, Washington (2017).
[77] Kingsbury D, Fredericks J, Qi Y, Wang Q, Wannemuehler M, Mochel J, Jergens A, Allenspach K. Watch It Grow. The Original Dog Mini-Gut. ISU College of Veterinary Medicine Winter Symposium, Ames (2017).
[78] Allenspach K, Mochel JP, Du Y, Priestnall S, Moore F, Slaytor M, Rodrigues A, Day M, Ackermann M, Krockenberger M, Mansell J, WSAVA GI Standardization Working Group, Suchodolski J, Berghoff N, Jergens AE. Correlating Gastrointestinal Histopathologic Findings to Clinical Disease Activity in Dogs with Idiopathic Inflammatory Bowel Disease. European College of Veterinary Internal Medicine Congress, Malta (2017).
[79] Allenspach K, Mochel JP, Suchodolski J, Jergens AE. Specific Virulence Factors in Mucosa-Associated E. coli of Dogs With Inflammatory Bowel Disease (IBD) Predict Survival. European College of Veterinary Internal Medicine Congress, Malta (2017).
[80] Sebbag L, Harrington D, Mochel JP. Tear Fluid Collection in Dogs and Cats Using Ophthalmic Sponges. American College of Veterinary Ophthalmologists Conference, Baltimore (2017).
[81] Mochel JP, Kingsbury D, Jergens AE, Allenspach K. Using Canine Intestinal Stem Cells to Advance Drug Development, Precision and Regenerative Medicine. ISU Faculty Research Symposium, Ames (2017).
[82] Smith JS, Zwueste D, Beahm A, Siegel K, Mochel JP, Winger K. Neurologic diseases of miniature companion pigs: 19 Cases (2000-2015). ISU Neuroscience Symposium, Ames (2017).
[83] Rowen NM, Mochel JP, Gannon M, Nelson M, LeVine DN. Regulation of Canine Neutrophil Extracellular Trap Formation by Immune-mediated Hemolytic Anemia Therapeutics. BIVI-NIH National Veterinary Scholars Symposium, Ames (2017).
[84] Hepner P, Sebbag L, Allbaugh R, Showman L, Perera A, Strong T, Mochel JP, Wiggans T, Maggs D. Metabolomics and Biochemical Analysis of Tears in Healthy Cats and in Cats Affected With Corneal Sequestrum. Merial-NIH National Veterinary Scholars Symposium, Ames (2017).
[85] Slagel C, Smith JS, Mochel JP, Plummer P. Concurrent Use of an Immunostimulant and Antibiotic Improves Treatment Outcome in a Sheep Model of Catheter-Associated Urinary Tract Disease Due to Pseudomonas Aeruginosa. BIVI-NIH National Veterinary Scholars Symposium, Ames (2017).
[86] McDowell W, Mochel JP, Showman L, Perera A, Hepner P, Sebbag L. Effect of Tear Collection Method on Total Protein Content and Drug Concentration in Tear Fluid of Dogs and Cats. NIH National Veterinary Scholars Symposium, Ames (2017).
[87] Mochel J, Danhof M. Pharmacodynamics of the Renin-Angiotensin Aldosterone System and Blood Pressure in Relation to Food Intake in Dogs. Population Approach Group in Europe (PAGE) Meeting, Lisbon (2016).
[88] Mochel J. Chronopharmacology of the Renin-Angiotensin Network in Dogs. The Value of Model-Based Approaches: Some ‘Food for Thought’. International Seminar Programme on Drug Innovation, Utrecht (2016).
[89] Mochel J, Seewald W, Danhof M. Pharmacokinetics of the Angiotensin Receptor-Neprilysin Inhibitor LCZ696 in Furosemide-Treated Dogs. European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
[90] Mochel J, Peyrou M, Giraudel J, Danhof M. First-In-Class Angiotensin Receptor-Neprilysin Inhibitor LCZ696 Markedly Influences the Dynamics of Circulating cGMP and Biomarkers of the Renin-Angiotensin Aldosterone System in Dogs. European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
[91] Mochel J. Chronopharmacology of the Renin-Angiotensin Aldosterone System in Dogs: The Value of PK/PD Modeling. European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
[92] Bieth B, Bornkamp B, Toutain C, Garcia R, Mochel J. Model-Based Dose-Response Analysis of Furosemide Effect on the Renin-Angiotensin Cascade and Diuresis in Dogs. European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
[93] Pelligand L, Mochel J. Monte Carlo Simulations and their Application in Veterinary Medicine. European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
[94] Pelligand L, Soubret A, King JN, Elliot J, Mochel J. Simultaneous Intravenous and Subcutaneous Population Modelling of Robenacoxib Disposition Kinetics in Cats. European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
[95] Mochel J, Bornkamp B, Bieth B. Evaluating the Dose-Response Relationship of Furosemide on Diuresis and RAAS Activation in Dogs Combining Multiple Comparisons and Modeling Techniques. Population Approach Group in Europe (PAGE) Meeting, Hersonissos (2015).
[96] Pelligand L, Renard D, Soubret A, King JN, Elliot J, Mochel J. Modeling of Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study with the Nonsteroidal Anti-Inflammatory Robenacoxib in Cats. Population Approach Group in Europe (PAGE) Meeting, Hersonissos (2015).
[97] Mochel J, Burkey B, Fink M, Garcia R, Peyrou M, Giraudel J, Renard D, Danhof M. First-In-Class Angiotensin Receptor Neprilysin Inhibitor LCZ696 Modulates the Dynamics of the Renin Cascade and Natriuretic Peptides System with Significant Reduction of Aldosterone Exposure. Annual Scientific Session of the American College of Cardiology, Washington (2014).
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