Dr. Jon P Mochel

Jon_MochelDr. Jon Mochel obtained his Veterinary Medical Degree from the National Veterinary School of Toulouse. In 2007, he completed his Doctorate studying Neurosciences in collaboration with the College de France (Paris), and received the Silver Medal from the National Veterinary School of Alfort for his work.

During his veterinary undergraduate studies Dr. Mochel also obtained a Masters in Pharmacology and Pharmacokinetics (2006) from the University of Toulouse. Following a Medical Internship in Veterinary Medicine and Surgery at Maisons-Alfort (2006-2008), he also got a Master of Science (MS) in Pharmacology and Pharmacokinetics from the University of Toulouse. He then pursued a 4-year Specialization program in Pharmacology and Toxicology (European Board) and earned his title of European Specialist in Veterinary Pharmacology and Toxicology.

Dr. Mochel did his Ph.D at Leiden University under the supervision of Pr. Meindert Danhof, whose focus was on the modeling of the dynamics of the renin-angiotensin aldosterone system (RAAS) in dogs.

In 2012, he co-founded the Animal Health Modeling & Simulation (AHM&S) Society, together with Pr. Johan Gabrielsson (University of Agricultural Sciences, Uppsala, Sweden), and Pr. Jim Riviere (Kansas State University, USA), which aims at promoting the development, application, and dissemination of Modeling and Simulation techniques in the field of Veterinary Sciences (http://www.ahmss.com/).

Since joining Novartis Pharmaceuticals in 2013, he had been working as a Senior Pharmacology Modeler in the Modeling and Simulation (M&S) group formed by Dr. Donald Stanski. He thereafter operated as a Quantitative Pharmacology Leader in the Research M&S department of Dr. Thierry Lave at Roche.

Dr. Mochel is currently an Associate Professor in the Department of Biomedical Sciences at Iowa State University and the Chair of the Education and Residency Committee of the European College of Pharmacology and Toxicology (http://www.ecvpt.org/).

His research, which falls under the scope of the One Health initiative, pertains to the analysis of clinical data obtained from spontaneous animal models of human diseases to bridge the knowledge gap between experimental (i.e rodent) models and patients.

Recent Publications (Last four years):

1: Masters AK, Berger DJ, Ware WA, Langenfeld NR, Coetzee JF, Mochel JP, Ward
JL. Effects of short-term anti-inflammatory glucocorticoid treatment on
clinicopathologic, echocardiographic, and hemodynamic variables in systemically
healthy dogs. Am J Vet Res. 2018 Apr;79(4):411-423. doi: 10.2460/ajvr.79.4.411.
PubMed PMID: 29583045.

2: Bon C, Toutain PL, Concordet D, Gehring R, Martin-Jimenez T, Smith J,
Pelligand L, Martinez M, Whittem T, Riviere JE, Mochel JP. Mathematical modeling
and simulation in animal health. Part III: Using nonlinear mixed-effects to
characterize and quantify variability in drug pharmacokinetics. J Vet Pharmacol
Ther. 2018 Apr;41(2):171-183. doi: 10.1111/jvp.12473. Epub 2017 Dec 11. Review.
PubMed PMID: 29226975.

3: Smith JS, Coetzee JF, Fisher IWG, Borts DJ, Mochel JP. Pharmacokinetics of
fentanyl citrate and norfentanyl in Holstein calves and effect of analytical
performances on fentanyl parameter estimation. J Vet Pharmacol Ther. 2018 Mar 30.
doi: 10.1111/jvp.12501. [Epub ahead of print] PubMed PMID: 29603262.

4: Sebbag L, McDowell EM, Hepner PM, Mochel JP. Effect of tear collection on
lacrimal total protein content in dogs and cats: a comparison between Schirmer
strips and ophthalmic sponges. BMC Vet Res. 2018 Mar 1;14(1):61. doi:
10.1186/s12917-018-1390-7. PubMed PMID: 29490661; PubMed Central PMCID:
PMC5831202.

5: Gorden PJ, Burchard M, Ydstie JA, Kleinhenz MD, Wulf LW, Rajewski SJ, Wang C,
Gehring R, Mochel JP, Coetzee JF. Comparison of milk and plasma pharmacokinetics
of meloxicam in postpartum versus mid-lactation Holstein cows. J Vet Pharmacol
Ther. 2018 Feb 11. doi: 10.1111/jvp.12488. [Epub ahead of print] PubMed PMID:
29430684.

6: Schneider B, Balbas-Martinez V, Jergens AE, Troconiz IF, Allenspach K, Mochel
JP
. Model-Based Reverse Translation Between Veterinary and Human Medicine: The
One Health Initiative. CPT Pharmacometrics Syst Pharmacol. 2018 Feb;7(2):65-68.
doi: 10.1002/psp4.12262. Epub 2017 Nov 27. PubMed PMID: 29178333; PubMed Central
PMCID: PMC5824107.

7: Mochel JP, Tyden E, Hellmann K, Vendrig JC, Şenel S, Dencker L, Cristina RT,
Linden H, Schmerold I. Network on veterinary medicines initiated by the European
Federation For Pharmaceutical Sciences. J Vet Pharmacol Ther. 2017 Dec 20. doi:
10.1111/jvp.12472. [Epub ahead of print] PubMed PMID: 29266320.

8: Mochel JP, Jergens AE, Kingsbury D, Kim HJ, Martín MG, Allenspach K.
Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative
Medicine: A Paradigm Shift in Translational Research. AAPS J. 2017 Dec
12;20(1):17. doi: 10.1208/s12248-017-0178-1. PubMed PMID: 29234895.

9: Sebbag L, Harrington DM, Mochel JP. Tear fluid collection in dogs and cats
using ophthalmic sponges. Vet Ophthalmol. 2017 Aug 27. doi: 10.1111/vop.12502.
[Epub ahead of print] PubMed PMID: 28845579.

10: Bieth B, Bornkamp B, Toutain C, Garcia R, Mochel JP. Multiple comparison
procedure and modeling: a versatile tool for evaluating dose-response
relationships in veterinary pharmacology - a case study with furosemide. J Vet
Pharmacol Ther. 2016 Dec;39(6):539-546. doi: 10.1111/jvp.12313. Epub 2016 May 11.
PubMed PMID: 27166146.

11: Pelligand L, Soubret A, King JN, Elliott J, Mochel JP. Modeling of Large
Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in
Veterinary Pharmacology. A Case Study With Robenacoxib in Cats. CPT
Pharmacometrics Syst Pharmacol. 2016 Nov;5(11):625-635. doi: 10.1002/psp4.12141.
Epub 2016 Oct 22. PubMed PMID: 27770596; PubMed Central PMCID: PMC5193001.

12: Lin Z, Gehring R, Mochel JP, Lavé T, Riviere JE. Mathematical modeling and
simulation in animal health - Part II: principles, methods, applications, and
value of physiologically based pharmacokinetic modeling in veterinary medicine
and food safety assessment. J Vet Pharmacol Ther. 2016 Oct;39(5):421-38. doi:
10.1111/jvp.12311. Epub 2016 Apr 17. Review. PubMed PMID: 27086878.

13: Riviere JE, Gabrielsson J, Fink M, Mochel J. Mathematical modeling and
simulation in animal health. Part I: Moving beyond pharmacokinetics. J Vet
Pharmacol Ther. 2016 Jun;39(3):213-23. doi: 10.1111/jvp.12278. Epub 2015 Nov 22.
Review. PubMed PMID: 26592724.

14: Mochel JP, Fink M, Peyrou M, Soubret A, Giraudel JM, Danhof M.
Pharmacokinetic/Pharmacodynamic Modeling of Renin-Angiotensin Aldosterone
Biomarkers Following Angiotensin-Converting Enzyme (ACE) Inhibition Therapy with
Benazepril in Dogs. Pharm Res. 2015 Jun;32(6):1931-46. doi:
10.1007/s11095-014-1587-9. Epub 2014 Dec 2. PubMed PMID: 25446774.

15: Mochel JP, Danhof M. Chronobiology and Pharmacologic Modulation of the
Renin-Angiotensin-Aldosterone System in Dogs: What Have We Learned? Rev Physiol
Biochem Pharmacol. 2015;169:43-69. doi: 10.1007/112_2015_27. Review. PubMed PMID:
26428686.

16: Mochel JP, Fink M, Bon C, Peyrou M, Bieth B, Desevaux C, Deurinck M, Giraudel
JM, Danhof M. Influence of feeding schedules on the chronobiology of renin
activity, urinary electrolytes and blood pressure in dogs. Chronobiol Int. 2014
Jun;31(5):715-30. doi: 10.3109/07420528.2014.897711. Epub 2014 Mar 21. PubMed
PMID: 24654920.

17: Mochel JP, Fink M, Peyrou M, Desevaux C, Deurinck M, Giraudel JM, Danhof M.
Chronobiology of the renin-angiotensin-aldosterone system in dogs: relation to
blood pressure and renal physiology. Chronobiol Int. 2013 Nov;30(9):1144-59. doi:
10.3109/07420528.2013.807275. Epub 2013 Aug 9. PubMed PMID: 23931032.

18: Fink M, Letellier I, Peyrou M, Mochel JP, Jung M, King JN, Gruet P, Giraudel
JM. Population pharmacokinetic analysis of blood concentrations of robenacoxib in
dogs with osteoarthritis. Res Vet Sci. 2013 Oct;95(2):580-7. doi:
10.1016/j.rvsc.2013.04.021. Epub 2013 May 31. PubMed PMID: 23726662.

19: Mochel JP, Gabrielsson J, Collard W, Fink M, Gehring R, Laffont C, Liu Y,
Martin-Jimenez T, Pelligand L, Steimer JL, Toutain PL, Whittem T, Riviere J.
Animal Health Modeling & Simulation Society: a new society promoting model-based
approaches in veterinary pharmacology. J Vet Pharmacol Ther. 2013 May 29. doi:
10.1111/jvp.12060. [Epub ahead of print] PubMed PMID: 23713757.

20: Mochel JP, Peyrou M, Fink M, Strehlau G, Mohamed R, Giraudel JM, Ploeger B,
Danhof M. Capturing the dynamics of systemic Renin-Angiotensin-Aldosterone System
(RAAS) peptides heightens the understanding of the effect of benazepril in dogs.
J Vet Pharmacol Ther. 2013 Apr;36(2):174-80. doi:
10.1111/j.1365-2885.2012.01406.x. Epub 2012 May 8. PubMed PMID: 22568394.