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SMART Pharmacology

Iowa State University

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Pharmacokinetic Modeling

Aqueous tear deficiency in cats


February 24, 2019April 10, 2019By
Aqueous tear deficiency in cats
Aqueous deficiency cat
Pharmacokinetic Modeling

Schirmer tear test is a reliable diagnostic tool in the general feline population


February 24, 2019April 10, 2019By
Schirmer tear test is a reliable diagnostic tool in the general feline population

(more…)

Pharmacodynamic Modeling

Determining Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer via Mathematical Modeling


February 22, 2019April 10, 2019By
Determining Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small Cell Lung Cancer via Mathematical Modeling

Bevacizumab-pemetrexed/cisplatin combination therapy (BEV-PEM/CIS) is a first line therapeutic for non-small cell lung cancer (NSCLC). (more…)

Pharmacodynamic Modeling

CAR T-Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies


December 5, 2018April 10, 2019By
CAR T-Cell Immunotherapy in Human and Veterinary Oncology:  Changing the Odds Against Hematological Malignancies

preprints201811.0525.v1

(more…)

Pharmacodynamic Modeling

Sacubitril/valsartan (LCZ696) Significantly Reduces Aldosterone and Increases cGMP Circulating Levels in a Canine Model of RAAS Activation


December 5, 2018April 10, 2019By
Sacubitril/valsartan (LCZ696) Significantly Reduces Aldosterone and Increases cGMP Circulating Levels in a Canine Model of RAAS Activation
pagination_PHASCI_4771

(more…)

Experimental Model Development

Adult Canine Intestinal Derived Organoids: A Novel In Vitro System for Translational Research in Comparative Gastroenterology


December 5, 2018April 10, 2019By
Adult Canine Intestinal Derived Organoids: A Novel In Vitro System for Translational Research in Comparative Gastroenterology
BioRxiv Submission

(more…)

Translational Pharmacology

One Health: Translational and Reverse Translational Modeling of Inflammatory Bowel Disease using an advanced Boolean Network


December 5, 2018April 10, 2019By
One Health: Translational and Reverse Translational Modeling of Inflammatory Bowel Disease using an advanced Boolean Network
PAGE 2017 IBD_One Health EdJM

(more…)

Translational Pharmacology

Pharmacokinetics of prednisone in tear fluid of dogs with or without conjunctivitis


October 22, 2018January 19, 2020By
Pharmacokinetics of prednisone in tear fluid of dogs with or without conjunctivitis

Full manuscript available here.

Presented as a Poster at the BIVI-NIH National Veterinary Scholar Symposium (Aug 2-5, 2018) and the Iowa State University’s CVM Summer Scholar Research Day (Aug 10, 2018)

Prednisone (2)

Pharmacokinetic Modeling

Drug quantification in tears of dogs and cats


October 22, 2018April 10, 2019By
Drug quantification in tears of dogs and cats

Full article available here

JOPT

Pharmacokinetic Modeling

Total protein content in tear fluid of dogs and cats


October 22, 2018April 10, 2019By
Total protein content in tear fluid of dogs and cats

Full article available here.

Effect of tear collection on lacrimal total protein content in dogs and cats - a comparison between Schirmer strips and ophthalmic sponges

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